Antimicrobial new therapies

Background: Patients with cystic fibrosis (CF) can be chronically infected with several pathogens, including S.aureus, P. aeruginosa, B. cepacia and others. By 18 years of age; 80% of patients are infected with P. aeruginosa (P.a.). With time, it converts to a mucoid phenotype which often heralds deterioration in respiratory status. Approximately 4% of patients in the U.S.A. become infected with B. cepacia complex, it can be particularly virulent and is associated with increased mortality…